Department color key
Physiology & Membrane Biology
Pharmacology
Cell Biology & Human Anatomy
Biochemistry & Molecular Medicine
Medical Microbiology & Immunology
Public Health Sciences
Review / Perspectives
Oct – Dec 2025 (2025 Q4)
▾
4 papers
Biochemistry & Molecular Medicine
Molecular Cell
Dec 2025
UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
Identifies UMP as a metabolic checkpoint for the tumor-suppressive transcription factor NR4A1, pointing to a novel combination therapeutic strategy for gastric cancer.
Neuron · Perspectives
Dec 2025
Scoping chromatin dynamics across cortical neurogenesis
Reviews SCOPE-C, a technique for simultaneously profiling chromatin accessibility and 3D regulatory contacts during cortical brain development — highlighting its implications for understanding neurodevelopmental disorders.
⚠ Perspectives piece — not primary research
Pharmacology
Cardiovascular Research
Nov 2025
Activated CaMKIIδ translocates to the RyR nanodomain in cardiomyocytes
Shows that CaMKIIδ relocates to ryanodine receptor nanoclusters during cardiac stimulation, redefining how calcium release is regulated during each heartbeat and opening new avenues for arrhythmia research.
Medical Microbiology & Immunology
J. Biological Chemistry
Epub Nov 2025
An evolutionary T119R substitution in macaque TIGIT enables proteolytic shedding and reveals clinical antibody vulnerabilities
Identifies a species-specific TIGIT difference that explains why TIGIT-targeting antibodies succeeded preclinically in macaques but failed in human cancer trials — a critical finding for immuno-oncology trial design.
Jan – Mar 2026 (2026 Q1)
▾
10 papers
Cell Biology & Human Anatomy
Nature Cell Biology
Feb 2026
Adaptor-mediated recruitment of three dyneins to dynactin enhances force generation
Demonstrates how adaptor proteins simultaneously recruit three dynein motors to dynactin, generating up to 9 pN of pulling force — a key mechanism for robust intracellular cargo transport under mechanical load.
Science Advances
Feb 2026
Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species
Shows that the angle of neural progenitor division governs brain and retinal size across species, with evolutionary implications for how mammalian nervous systems scale in complexity.
Pharmacology
Nature Communications
Jan 2026
Structural basis for the subtype-selectivity of KCa2.2 channel activators
Cryo-EM structures of the KCa2.2 channel bound to rimtuzalcap establish a structural blueprint for designing highly selective neurological therapeutics targeting small-conductance calcium-activated potassium channels.
Medical Microbiology & Immunology
Nature Communications
Jan 2026
Intelectin-2 is a broad-spectrum antimicrobial lectin
Identifies intelectin-2 as a dual-function mucosal immune protein that both kills microbes and reinforces the mucus barrier — with implications for IBD, infection susceptibility, and mucosal vaccine design.
mBio
Feb 2026
A new mouse model of typhoid fever using Salmonella Paratyphi C as a surrogate pathogen
Develops an improved small-animal model for drug-resistant typhoid fever and vaccine testing, addressing a long-standing gap in the field caused by host-specificity of S. Typhi.
Physiology & Membrane Biology
J. Physiology · Perspectives
Jan 2026
Piezo1 in intestinal smooth muscle cells: Emerging perspectives
Highlights Piezo1's role in mechanosensing and regulation of intestinal muscle contractions, with implications for understanding gut motility disorders.
⚠ Perspectives piece — not primary research
Journal of Physiology
Feb 2026
Kidney disease impairs tendon function in rats
First direct evidence that chronic kidney disease mechanically weakens tendons, establishing a validated animal model for studying and reversing musculoskeletal complications of CKD.
Public Health Sciences
Nature Medicine
Mar 2026
Deleterious coding variation associated with autism is shared across ancestries
The largest sequencing study of autism in Latin American individuals (n > 15,000) identifies 35 genome-wide significant autism-associated genes with substantial overlap across ancestries, demonstrating that autism biology is consistent across populations and supporting the utility of genetic testing in diverse backgrounds.
Environment International
Feb 2026
Prenatal exposure to wildfire-related PM2.5 and autism spectrum disorder in children born in California between 2001–2019
Analysis of 8.6 million California births reveals that intense wildfire smoke exposure during pregnancy increases ASD risk by up to 50%, particularly in low-background-pollution and rural settings — underscoring the need for targeted policies as wildfire frequency rises.
Environmental Epidemiology
Jan 2026
Trees — not grass and other greenery — associated with lower heart disease risk in cities
Using over 350 million street-view images across the Nurses’ Health Study, finds that urban tree canopy is associated with a 4% decrease in cardiovascular disease, while grass and shrubs show no benefit or a slight increase — with implications for urban planning and environmental health policy.